ANTAGONISM OF BENZODIAZEPINE SEDATION WITH FLUMAZENIL
نویسندگان
چکیده
منابع مشابه
Antagonism of diazepam sedation by flumazenil.
Forty adult patients undergoing elective surgery, anaesthetized with diazepam, alfentanil and nitrous oxide in oxygen, and paralysed with atracurium were given flumazenil or placebo i.v. in a double-blind randomized study to assess the efficacy of flumazenil. Awake state, heart rate, arterial pressure, rate of ventilation and arterial blood-gas values were measured at 0, 5, 30, 120 and 240 min ...
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Flumazenil is a specific benzodiazepine (BZD) antagonist which inhibits the effects of BZD agonists by competing for the receptor site in the central nervous system. It has completed clinical trials in the United States and received final approval from the U.S. Food and Drug Administration for release in January 1992. Following intravenous injection, clinically apparent arousal usually occurs w...
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Midazolam was used for anaesthesia in 20 patients undergoing cardioversion; 10 received flumazenil, which caused immediate rapid reversal of anaesthesia, and these patients maintained SpO2 greater than 95%, breathing air, within 5-10 min. In contrast, patients in the placebo group were still partially sedated and required oxygen therapy for up to 2 h to maintain a normal SpO2. Arterial pressure...
متن کاملEFFICACY OF FLUMAZENIL IN THE MANAGEMENT OF BENZODIAZEPINE OVERDOSE
Benzodiazepine overdose is the most commonly encountered drug overdose in Iran. It has been reported by many authors that flumazenil possesses highly specific antagonistic activity on central benzodiazepine receptors. We conducted a prospective study on 150 patients brought to the toxicology emergency ward in Loghman-Hakim hospital with benzodiazepine overdose to assess the efficacy of flu...
متن کاملAdvantages and problems with benzodiazepine sedation.
he benzodiazepines are the second group of drugs used by anesthetists that could truly be called "multipurpose," the first being the phenothiazines. The most popular of the latter, chlorpromazine, is known by the trade name Largactil in Europe, indicating the multiplicity of fields in which it can be used. While the phenothiazines were the more versatile of the two, they were also the more toxi...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1991
ISSN: 0007-0912
DOI: 10.1093/bja/67.4.504